The ability of a drug or probe to cross a biological barrier has historically been viewed to be
a function of its intrinsic physical properties. This view has largely restricted drug design and …

Remarkable findings have cemented the central dogma of biology, where the transfer of
genetic information from a sequence of nucleotides in DNA to a string of amino acids in …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …

The emerging field of glycomics has been challenged by difficulties associated with studying
complex carbohydrates and glycoconjugates. Advances in the development of synthetic …

Synthetic carbohydrates and glycoconjugates are used to study their roles in biological
important processes such as inflammation, cell–cell recognition, immunological response …

Molecular transporters have the ability to deliver drugs and probe molecules into cells and
tissues irrespective of their physical properties. We now report the design, synthesis, and …

Aminoglycosides (including neomycin B and tobramycin) exhibit poor uptake by eukaryotic
cell lines. When the amines of these natural products are converted into guanidine groups …

A series of water-soluble chitosan-N-arginine (CS-N-Arg) with various degrees of
substitution (DSs) from 8.7 to 28.4% was synthesized by reacting amino groups of chitosan …

Polymyxins are considered a last-line treatment against infections caused by multidrug-
resistant (MDR) Gram-negative bacteria. In addition to their use as a potent antibiotic …

Protein synthesis by the ribosome is the final stage of biological information transfer and
represents an irreversible commitment to gene expression. Accurate translation of …