Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

Introduction The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription
factor that controls the expression of numerous cytoprotective genes and regulates cellular …

Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant
modification of the tumour's bioenergetics provides energy for tumour growth and …

Prostate cancer (PCa) represents the second most common cancer in men and affects
millions worldwide. Chemotherapy is a common treatment for PCa but the development of …

Pancreatic cancer is a disease in which deregulation of signaling pathways plays a key role,
thus searching for their novel modulators is a promising therapeutic strategy. Hence, in this …

Background Bicalutamide is a nonsteroidal antiandrogen widely used as a first-line clinical
treatment for advanced prostate cancer (PCa). Although patients initially show effective …

Alpha-lipoic acid (ALA) is a natural antioxidant dithiol compound, exerting antiproliferative
and antimetastatic effects in various cancer cell lines. In our study, we demonstrated that …

Heme oxygenase 1 (HO-1) is a detoxifying antioxidant microsomal enzyme that regulates
inflammation, apoptosis, cell proliferation, and angiogenesis in prostate cancer (PCa). This …

Prostate cancer (PCa) is the most prevalent men's cancer in America and Western countries.
No effective therapies are currently available for PCa aggressiveness, including castration …

Prostate cancer (PC) is a significant cause of mortality in men worldwide, hence the need for
a comprehensive understanding of the molecular mechanisms underlying its progression …