The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of
two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular …

Tumor cells display increased metabolic autonomy in comparison to non-transformed cells,
taking up nutrients and metabolizing them in pathways that support growth and proliferation …

Amino acids control cell growth via activation of the highly conserved kinase TORC1.
Glutamine is a particularly important amino acid in cell growth control and metabolism …

The altered metabolism of tumors has been considered a target for anticancer therapy.
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …

Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes
the propensity of most cancer cells to take up glucose avidly and convert it primarily to …

We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a
key enzyme in conversion of glutamine to glutamate, and thereby a regulator of glutathione …

The idea that conversion of glucose to ATP is an attractive target for cancer therapy has
been supported in part by the observation that glucose deprivation induces apoptosis in …

Abstract l-Glutamine is a nutritionally semi-essential amino acid for proper growth in most
cells and tissues, and plays an important role in the determination and guarding of the …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is
essential for proliferation of most cancer cells, which makes glutamine an appealing target …