Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

Many fundamental cellular processes such as division, polarization, endocytosis, and
motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) …

Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust
enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far …

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …

Nascent proteins can be positioned rapidly at precise subcellular locations by local protein
synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major …

Localization and translation of mRNAs within different subcellular domains provides an
important mechanism to spatially and temporally introduce new proteins in polarized cells …

Various species of non‐coding RNA s (ncRNAs) are enriched in specific subcellular
compartments, but the mechanisms orchestrating their localization and their local functions …

Axons need to be properly guided to their targets to form synaptic connections, and this
requires interactions between highly conserved extracellular and transmembrane ligands …

The actin cytoskeleton plays key roles in every eukaryotic cell and is essential for cell
adhesion, migration, mechanosensing, and contractility in muscle and non-muscle tissues …