SLC6 neurotransmitter transporters: structure, function, and regulation
AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - Elsevier
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
Mechanisms of dopamine transporter regulation in normal and disease states
RA Vaughan, JD Foster - Trends in pharmacological sciences, 2013 - cell.com
The dopamine (DA) transporter (DAT) controls the spatial and temporal dynamics of DA
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …
Plasma membrane monoamine transporters: structure, regulation and function
The classical biogenic amine neurotransmitters—dopamine, noradrenaline, and 5-
hydroxytryptamine—control a variety of functions including locomotion, autonomic function …
hydroxytryptamine—control a variety of functions including locomotion, autonomic function …
SLC6 transporters: structure, function, regulation, disease association and therapeutics
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease
CL German, MG Baladi, LM McFadden… - Pharmacological …, 2015 - Elsevier
Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …
Synaptic uptake and beyond: the sodium-and chloride-dependent neurotransmitter transporter family SLC6
NH Chen, MEA Reith, MW Quick - Pflügers Archiv, 2004 - Springer
The SLC6 family is a diverse set of transporters that mediate solute translocation across cell
plasma membranes by coupling solute transport to the cotransport of sodium and chloride …
plasma membranes by coupling solute transport to the cotransport of sodium and chloride …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
Neurotransmitter transporters: molecular function of important drug targets
U Gether, PH Andersen, OM Larsson… - Trends in …, 2006 - cell.com
The concentration of neurotransmitters in the extracellular space is tightly controlled by
distinct classes of membrane transport proteins. This review focuses on the molecular …
distinct classes of membrane transport proteins. This review focuses on the molecular …
N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux
H Khoshbouei, N Sen, B Guptaroy, LA Johnson… - PLoS …, 2004 - journals.plos.org
Amphetamine (AMPH) elicits its behavioral effects by acting on the dopamine (DA)
transporter (DAT) to induce DA efflux into the synaptic cleft. We previously demonstrated that …
transporter (DAT) to induce DA efflux into the synaptic cleft. We previously demonstrated that …
Monoamine transporters and psychostimulant addiction
LL Howell, HL Kimmel - Biochemical pharmacology, 2008 - Elsevier
Psychostimulants are a broadly defined class of drugs that stimulate the central and
peripheral nervous systems as their primary pharmacological effect. The abuse liability of …
peripheral nervous systems as their primary pharmacological effect. The abuse liability of …