Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 …

Depression constitutes the most frequent comorbid condition associated with rheumatoid
arthritis (RA), with prevalence rates ranging from 14% to 48%. This wide range can be …

Importance Posttraumatic stress disorder (PTSD) is a prevalent, serious public health
concern, particularly in the military. The identification of genetic risk factors for PTSD may …

Awareness of a bidirectional relationship between depression and RA through a
biopsychosocial framework may assist clinicians in maintaining an appropriate index of …

Introduction: Most arthritides are associated with pain and psychological distress (clinically
significant depression and anxiety). Pain and depression are mutually exacerbating; both …

Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or
threatened. Stress is not always perceived as a negative response. Stress results when …

Background Increasing evidence suggests a link between posttraumatic stress disorder
(PTSD) and physical health. Stress disorders may lead to impairment of the immune system …

Links between the central nervous stress system and peripheral immune cells in lymphoid
organs have been detailed through 50 years of intensive research. The brain can interfere …