Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Background Recent studies demonstrated that the triple combination cystic fibrosis
transmembrane conductance regulator (CFTR) modulator therapy elexacaftor/tezacaftor …

Mucus is a viscoelastic material with non-linear rheological properties such as yield stress of
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …

Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Here, novel lipid–polymer hybrid nanoparticles (LPHNPs), targeted to lung macrophages,
were realized as potential carriers for Roflumilast administration in the management of …

Cystic fibrosis (CF) is a muco-obstructive lung disease where inflammatory responses due to
chronic infection result in the accumulation of neutrophil extracellular traps (NETs) in the …

Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the
composition and physical properties of these secretions are poorly understood. We …

The respiratory tract harbors a stable and diverse microbial population within an
extracellular mucus layer. Mucus provides a formidable defense against infection and …

Biofilm-associated infections (BAI) are chronic infections that are refractory to standard
antibiotic therapy and challenging to diagnose. Detecting biofilms in patients remains a …