Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis
MH Nematollahi, M Mehrabani, Y Hozhabri… - Heliyon, 2023 - cell.com
Chalcones and their derivatives have been widely studied due to their versatile
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …
Synthesis, Anticancer Assessment, and Molecular Docking of Novel Chalcone‐Thienopyrimidine Derivatives in HepG2 and MCF‐7 Cell Lines
GM Safwat, KMA Hassanin… - Oxidative medicine …, 2021 - Wiley Online Library
Heterocycles containing thienopyrimidine moieties have attracted attention due to their
interesting biological and pharmacological activities. In this research article, we reported the …
interesting biological and pharmacological activities. In this research article, we reported the …
Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives
K Sanachai, T Aiebchun, P Mahalapbutr… - RSC Medicinal …, 2021 - pubs.rsc.org
The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been
considered as potential targets for cancer therapy due to their role in regulating proliferation …
considered as potential targets for cancer therapy due to their role in regulating proliferation …
Antiproliferative effect of acridine chalcone is mediated by induction of oxidative stress
P Takac, M Kello, M Vilkova, J Vaskova, R Michalkova… - Biomolecules, 2020 - mdpi.com
Chalcones are naturally occurring phytochemicals with diverse biological activities including
antioxidant, antiproliferative, and anticancer effects. Some studies indicate that the …
antioxidant, antiproliferative, and anticancer effects. Some studies indicate that the …
Determination of Chemical Composition, In Vitro and In Silico Evaluation of Essential Oil from Leaves of Apium graveolens Grown in Saudi Arabia
The aim of this study was to explore the composition and evaluate the in silico and in vitro
antioxidants and antimicrobial and anti-inflammatory effects of Apium graveolens var. dulce …
antioxidants and antimicrobial and anti-inflammatory effects of Apium graveolens var. dulce …
Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor
The enhancement of drug efflux caused by ATP-binding cassette (ABC) transporters
(including ABCG2 and ABCB1) overexpression is an important factor for multidrug …
(including ABCG2 and ABCB1) overexpression is an important factor for multidrug …
2-Aryl-3-(6-trifluoromethoxy) benzo [d] thiazole-based thiazolidinone hybrids as potential anti-infective agents: Synthesis, biological evaluation and molecular docking …
The search for new antimicrobial agents is greater than ever due to the perpetual threat of
multidrug resistance in known pathogens and the relentless emergence of new infections. In …
multidrug resistance in known pathogens and the relentless emergence of new infections. In …
Thiazole-based chalcone derivatives as potential anti-inflammatory agents: Biological evaluation and molecular modelling
Background: Inflammation is a multifactorial process reflecting the response of the organism
to various stimuli and is associated with a number of disorders such as arthritis, asthma and …
to various stimuli and is associated with a number of disorders such as arthritis, asthma and …
Nonlinear optical and spectroscopic properties, thermal analysis, and hemolytic capacity evaluation of quinoline-1, 3-benzodioxole chalcone
This article describes the synthesis, characterization (1H NMR, 13C NMR, FT-IR, HRMS and
XRD), UV-Vis absorption and fluorescence spectra, theoretical analysis, evaluation of …
XRD), UV-Vis absorption and fluorescence spectra, theoretical analysis, evaluation of …