Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis

MH Nematollahi, M Mehrabani, Y Hozhabri… - Heliyon, 2023 - cell.com
Chalcones and their derivatives have been widely studied due to their versatile
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …

Synthesis, Anticancer Assessment, and Molecular Docking of Novel Chalcone‐Thienopyrimidine Derivatives in HepG2 and MCF‐7 Cell Lines

GM Safwat, KMA Hassanin… - Oxidative medicine …, 2021 - Wiley Online Library
Heterocycles containing thienopyrimidine moieties have attracted attention due to their
interesting biological and pharmacological activities. In this research article, we reported the …

Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives

K Sanachai, T Aiebchun, P Mahalapbutr… - RSC Medicinal …, 2021 - pubs.rsc.org
The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been
considered as potential targets for cancer therapy due to their role in regulating proliferation …

Antiproliferative effect of acridine chalcone is mediated by induction of oxidative stress

P Takac, M Kello, M Vilkova, J Vaskova, R Michalkova… - Biomolecules, 2020 - mdpi.com
Chalcones are naturally occurring phytochemicals with diverse biological activities including
antioxidant, antiproliferative, and anticancer effects. Some studies indicate that the …

Determination of Chemical Composition, In Vitro and In Silico Evaluation of Essential Oil from Leaves of Apium graveolens Grown in Saudi Arabia

AI Foudah, MH Alqarni, A Alam, MA Salkini, P Alam… - Molecules, 2021 - mdpi.com
The aim of this study was to explore the composition and evaluate the in silico and in vitro
antioxidants and antimicrobial and anti-inflammatory effects of Apium graveolens var. dulce …

Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor

CY Cai, W Zhang, JQ Wang, ZN Lei, YK Zhang… - Biochemical …, 2020 - Elsevier
The enhancement of drug efflux caused by ATP-binding cassette (ABC) transporters
(including ABCG2 and ABCB1) overexpression is an important factor for multidrug …

2-Aryl-3-(6-trifluoromethoxy) benzo [d] thiazole-based thiazolidinone hybrids as potential anti-infective agents: Synthesis, biological evaluation and molecular docking …

M Haroun, C Tratrat, A Petrou, A Geronikaki… - Bioorganic & Medicinal …, 2021 - Elsevier
The search for new antimicrobial agents is greater than ever due to the perpetual threat of
multidrug resistance in known pathogens and the relentless emergence of new infections. In …

Thiazole-based chalcone derivatives as potential anti-inflammatory agents: Biological evaluation and molecular modelling

C Tratrat, M Haroun, E Tsolaki, A Petrou… - Current Topics in …, 2021 - ingentaconnect.com
Background: Inflammation is a multifactorial process reflecting the response of the organism
to various stimuli and is associated with a number of disorders such as arthritis, asthma and …

Nonlinear optical and spectroscopic properties, thermal analysis, and hemolytic capacity evaluation of quinoline-1, 3-benzodioxole chalcone

E Polo-Cuadrado, E Osorio, K Acosta-Quiroga… - RSC …, 2024 - pubs.rsc.org
This article describes the synthesis, characterization (1H NMR, 13C NMR, FT-IR, HRMS and
XRD), UV-Vis absorption and fluorescence spectra, theoretical analysis, evaluation of …