Conventional transnasal brain-targeted drug delivery strategies are limited by nasal cilia
clearance and the nasal mucosal barrier. To address this challenge, we designed dissolving …

Synapses serve as the points of communication between neurons, consisting primarily of
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …

Alzheimer's disease (AD) is a prevalent and debilitating brain disorder that worsens
progressively with age, characterized by cognitive decline and memory impairment. The …

Epilepsy and Alzheimer's disease share some common pathologies such as
neurodegeneration, seizures and impaired cognition. However, the molecular mechanisms …

Amyloid precursor protein (APP) is predominantly located in synapses of neurons and its
mutations have been well recognized as the most important genetic causal factor for the …

Aging presents progressive changes that increase the susceptibility of the central nervous
system (CNS) to suffer neurological disorders (NDs). Several studies have reported that an …

Introduction Dual specificity protein phosphatase 6 (DUSP6) was recently identified as a key
hub gene in a causal VGF gene network that regulates late-onset Alzheimer's disease (AD) …

Introduction Whether repeated inhalation of sevoflurane during the neonatal period causes
long-term learning and memory impairments in humans is unclear. Some recent …

Fyn kinase SH3 domain interaction with PXXP motif in the Tau protein is implicated in AD
pathology and is central to NMDAR function. Among seven PXXP motifs localized in proline …

For decades, researchers have studied how brain tumors, the immune system, and drugs
interact. With the advances in cancer neuroscience, which centers on defining and …