Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?

VT Karamyan - Physiological Reports, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with …

The role of peptidase neurolysin in neuroprotection and neural repair after stroke

VT Karamyan - Neural Regeneration Research, 2021 - journals.lww.com
Current experimental stroke research has evolved to focus on detailed understanding of the
brain's self-protective and restorative mechanisms, and harness this knowledge for …

Modeling SARS-CoV-2 spike/ACE2 protein–protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related …

V Tragni, F Preziusi, L Laera, A Onofrio, I Mercurio… - EPMA Journal, 2022 - Springer
Aims The rapid spread of new SARS-CoV-2 variants has highlighted the crucial role played
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …

Cryo‐EM reveals mechanisms of angiotensin I‐converting enzyme allostery and dimerization

L Lubbe, BT Sewell, JD Woodward… - The EMBO Journal, 2022 - embopress.org
Hypertension (high blood pressure) is a major risk factor for cardiovascular disease, which is
the leading cause of death worldwide. The somatic isoform of angiotensin I‐converting …

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

S Mirali, A Botham, V Voisin, C Xu… - Science Translational …, 2020 - science.org
Neurolysin (NLN) is a zinc metallopeptidase whose mitochondrial function is unclear. We
found that NLN was overexpressed in almost half of patients with acute myeloid leukemia …

Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis

N Nagano, Y Ichihashi, T Komatsu, H Matsuzaki… - Chemical …, 2023 - pubs.rsc.org
The M3 metalloproteases, neurolysin and THOP1, are neuropeptidases that are expressed
in various tissues and metabolize neuropeptides, such as neurotensin. The biological roles …

Rules governing metal coordination in Aβ–Zn (ii) complex models from quantum mechanical calculations

J Aduriz-Arrizabalaga, JM Mercero… - Physical Chemistry …, 2023 - pubs.rsc.org
Transition metals directly contribute to the neurotoxicity of the aggregates of the amyloid-
forming Aβ peptide. The understanding and rationalization of the coordination modes of …

The peptidases involved in plant mitochondrial protein import

AS Ghifari, S Huang, MW Murcha - Journal of experimental …, 2019 - academic.oup.com
The endosymbiotic origin of the mitochondrion and the subsequent transfer of its genome to
the host nucleus has resulted in intricate mechanisms of regulating mitochondrial …

Discovery of first-in-class peptidomimetic neurolysin activators possessing enhanced brain penetration and stability

MS Rahman, S Kumari, SH Esfahani… - Journal of medicinal …, 2021 - ACS Publications
Peptidase neurolysin (Nln) is an enzyme that functions to cleave various neuropeptides.
Upregulation of Nln after stroke has identified the enzyme as a critical endogenous …

Proteomic characterization of synaptosomes from human substantia nigra indicates altered mitochondrial translation in Parkinson's disease

S Plum, B Eggers, S Helling, M Stepath, C Theiss… - Cells, 2020 - mdpi.com
The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-
containing dopaminergic neurons within the substantia nigra pars compacta (SNpc) …