Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
VT Karamyan - Physiological Reports, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with …
syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with …
The role of peptidase neurolysin in neuroprotection and neural repair after stroke
VT Karamyan - Neural Regeneration Research, 2021 - journals.lww.com
Current experimental stroke research has evolved to focus on detailed understanding of the
brain's self-protective and restorative mechanisms, and harness this knowledge for …
brain's self-protective and restorative mechanisms, and harness this knowledge for …
Modeling SARS-CoV-2 spike/ACE2 protein–protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related …
V Tragni, F Preziusi, L Laera, A Onofrio, I Mercurio… - EPMA Journal, 2022 - Springer
Aims The rapid spread of new SARS-CoV-2 variants has highlighted the crucial role played
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …
Cryo‐EM reveals mechanisms of angiotensin I‐converting enzyme allostery and dimerization
Hypertension (high blood pressure) is a major risk factor for cardiovascular disease, which is
the leading cause of death worldwide. The somatic isoform of angiotensin I‐converting …
the leading cause of death worldwide. The somatic isoform of angiotensin I‐converting …
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability
S Mirali, A Botham, V Voisin, C Xu… - Science Translational …, 2020 - science.org
Neurolysin (NLN) is a zinc metallopeptidase whose mitochondrial function is unclear. We
found that NLN was overexpressed in almost half of patients with acute myeloid leukemia …
found that NLN was overexpressed in almost half of patients with acute myeloid leukemia …
Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
N Nagano, Y Ichihashi, T Komatsu, H Matsuzaki… - Chemical …, 2023 - pubs.rsc.org
The M3 metalloproteases, neurolysin and THOP1, are neuropeptidases that are expressed
in various tissues and metabolize neuropeptides, such as neurotensin. The biological roles …
in various tissues and metabolize neuropeptides, such as neurotensin. The biological roles …
Rules governing metal coordination in Aβ–Zn (ii) complex models from quantum mechanical calculations
J Aduriz-Arrizabalaga, JM Mercero… - Physical Chemistry …, 2023 - pubs.rsc.org
Transition metals directly contribute to the neurotoxicity of the aggregates of the amyloid-
forming Aβ peptide. The understanding and rationalization of the coordination modes of …
forming Aβ peptide. The understanding and rationalization of the coordination modes of …
The peptidases involved in plant mitochondrial protein import
The endosymbiotic origin of the mitochondrion and the subsequent transfer of its genome to
the host nucleus has resulted in intricate mechanisms of regulating mitochondrial …
the host nucleus has resulted in intricate mechanisms of regulating mitochondrial …
Discovery of first-in-class peptidomimetic neurolysin activators possessing enhanced brain penetration and stability
Peptidase neurolysin (Nln) is an enzyme that functions to cleave various neuropeptides.
Upregulation of Nln after stroke has identified the enzyme as a critical endogenous …
Upregulation of Nln after stroke has identified the enzyme as a critical endogenous …
Proteomic characterization of synaptosomes from human substantia nigra indicates altered mitochondrial translation in Parkinson's disease
S Plum, B Eggers, S Helling, M Stepath, C Theiss… - Cells, 2020 - mdpi.com
The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-
containing dopaminergic neurons within the substantia nigra pars compacta (SNpc) …
containing dopaminergic neurons within the substantia nigra pars compacta (SNpc) …