Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

OBJECTIVES: This review aims to define the concept of neuromuscular fatigue and to
present the current knowledge of the central and peripheral factors at the origin of this …

Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

▪ Abstract X-ray crystallography shows the myosin cross-bridge to exist in two conformations,
the beginning and end of the “power stroke.” A long lever-arm undergoes a 60° to 70° …

Muscle contraction and a range of critical cellular functions rely on force-producing
interactions between myosin motors and actin filaments, powered by turnover of adenosine …

Publisher Summary This chapter describes the analysis of the polymorphism of the myosin
crossbridge and relates it to the Lymn–Taylor crossbridge cycle. Myosin from muscle …

Myosin V is an unconventional myosin proposed to be processive on actin filaments,
analogous to kinesin on a microtubule [Mehta, AD, et al.(1999) Nature (London) 400, 590 …

Contraction of skeletal muscle cells is initiated by a well-known signaling pathway. An action
potential in a motor nerve triggers an action potential in a muscle cell membrane, a transient …