Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

The cytosol-facing membranes of cellular organelles contain proteins that enable signal
transduction, regulation of morphology and trafficking, protein import and export, and other …

Mitochondria are energy factories of cells and are important pivots for intracellular
interactions with other organelles. They interact with the endoplasmic reticulum …

Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation,
however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA …

Sites of close contact between mitochondria and the endoplasmic reticulum (ER) are known
as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and …

Studying organelles in isolation has been proven to be indispensable for deciphering the
underlying mechanisms of molecular cell biology. However, observing organelles in intact …

The recent discovery of interconnections between the endoplasmic reticulum (ER)
membrane and those of almost all the cell compartments is providing novel perspectives for …