Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

Hyaluronic acid (HA) is a primary component of the brain extracellular matrix and functions
through cellular receptors to regulate cell behavior within the central nervous system (CNS) …

Osteocytes are differentiated osteoblasts that become surrounded by matrix during the
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

CD44 is the major surface hyaluronan (HA) receptor implicated in intercellular and cell-
matrix adhesion, cell migration and signaling. It is a transmembrane, highly glycosylated …

Rewiring of synaptic circuitry pertinent to memory formation has been associated with
morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling …

Tissue regeneration is an active multiplex process involving the dynamic inflammatory
microenvironment. Under a normal physiological framework, inflammation is necessary for …

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor and the
sixth most common cancer worldwide. Current treatment strategies for HNSCC are surgery …

Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …