The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Abstract The Ensembl project (https://www. ensembl. org) annotates genomes and
disseminates genomic data for vertebrate species. We create detailed and comprehensive …

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …

Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

Outbreaks of emerging infectious diseases are occurring with increasing frequency and
consequences, including wildlife diseases and zoonoses. Those have potentially long …

Underrepresented populations are often excluded from genomic studies due in part to a lack
of resources supporting their analyses. The 1000 Genomes Project (1kGP) and Human …

In 1955, René Dubos famously expressed his “second thoughts on the germ theory”,
attributing infectious diseases to various “changing circumstances” that weaken the host by …

Ancient genomics can directly detect human genetic adaptation to environmental cues.
However, it remains unclear how pathogens have exerted selective pressures on human …

Malaria has had a major effect on the human genome, with many protective polymorphisms—
such as the sickle-cell trait—having been selected to high frequencies in malaria-endemic …