Protein aggregation and neurodegenerative diseases: From theory to therapy
The study of protein misfolding and aggregation saw resurgence in the last decade.
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
The prion protein (PrPC) is a central player in neurodegenerative diseases, such as prion
diseases or Alzheimer's disease. In contrast to disease-promoting cell surface PrPC …
diseases or Alzheimer's disease. In contrast to disease-promoting cell surface PrPC …
Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase
C Coelho, A Foti, T Hartmann, T Santos-Silva… - Nature chemical …, 2015 - nature.com
Aldehyde oxidase (AOX) is a xanthine oxidase (XO)-related enzyme with emerging
importance due to its role in the metabolism of drugs and xenobiotics. We report the first …
importance due to its role in the metabolism of drugs and xenobiotics. We report the first …
Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating …
Q Yu, Q Cai, W Liang, K Zhong, J Liu, H Li… - European Journal of …, 2023 - Elsevier
Multidrug-resistant bacteria infections pose an increasingly serious threat to human health,
and the development of antimicrobials is far from meeting the clinical demand. It is urgent to …
and the development of antimicrobials is far from meeting the clinical demand. It is urgent to …
Transition of the prion protein from a structured cellular form (PrPC) to the infectious scrapie agent (PrPSc)
PK Baral, J Yin, A Aguzzi, MNG James - Protein Science, 2019 - Wiley Online Library
Prion diseases in mammals are caused by a conformational transition of the cellular prion
protein from its native conformation (PrPC) to a pathological isoform called “prion protein …
protein from its native conformation (PrPC) to a pathological isoform called “prion protein …
Pharmacological agents targeting the cellular prion protein
Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a
glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded …
glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded …
Molecular mechanism of the misfolding and oligomerization of the prion protein: current understanding and its implications
J Singh, JB Udgaonkar - Biochemistry, 2015 - ACS Publications
Prion diseases, also known as transmissible spongiform encephalopathies, make up a
group of fatal neurodegenerative disorders linked with the misfolding and aggregation of the …
group of fatal neurodegenerative disorders linked with the misfolding and aggregation of the …
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
R Abskharon, F Wang, A Wohlkonig, J Ruan… - PLoS …, 2019 - journals.plos.org
Prion or PrPSc is the proteinaceous infectious agent causing prion diseases in various
mammalian species. Despite decades of research, the structural basis for PrPSc formation …
mammalian species. Despite decades of research, the structural basis for PrPSc formation …
Unraveling the key to the resistance of canids to prion diseases
One of the characteristics of prions is their ability to infect some species but not others and
prion resistant species have been of special interest because of their potential in …
prion resistant species have been of special interest because of their potential in …