Tissue engineered nerve grafts (TENGs) have emerged as a potential alternative to
autologous nerve grafts, the gold standard for peripheral nerve repair. Typically, TENGs are …

Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the
gold standard autograft) and its main clinically approved alternative—hollow nerve guidance …

Due to the complex structural hierarchy and regenerative microenvironment of peripheral
nerves, developing a nerve guidance conduit (NGC) that can replace autografts for repairing …

Repairing peripheral nerve injury, especially long-range defects of thick nerves, is a great
challenge in the clinic due to their limited regeneration capability. Most FDA-approved nerve …

The current trend of peripheral nerve tissue engineering is the design of advanced nerve
guidance channels (NGCs) acting as physical guidance for regeneration of nerves across …

Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

Nerve regeneration after injury is a critical medical issue. In previous work, we have
developed an oligo (poly (ethylene glycol) fumarate)(OPF) hydrogel incorporated with …

In the body, cells encounter a complex milieu of signals, including topographical cues, in the
form of the physical features of their surrounding environment. Imposed topography can …

Despite the progress in understanding the pathophysiology of peripheral nervous system
injury and regeneration, as well as advancements in microsurgical techniques, peripheral …

Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft
repair. The first biodegradable empty single lumen or hollow nerve tubes are currently …