Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Tumor formation and growth depend on various biological metabolism processes that are
distinctly different with normal tissues. Abnormal energy metabolism is one of the typical …

Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

Recent studies have demonstrated that gastric cancer stem cells (CSCs) are a rare sub-
group of gastric cancer (GC) cells and have an important role in promoting the tumor growth …

Aerobic glycolysis, ie., the Warburg effect, may contribute to the aggressive phenotype of
hepatocellular carcinoma. However, increasing evidence highlights the limitations of the …

Most cancer‐related deaths result from the progressive growth of metastases. Patients with
peritoneal metastatic (PM) colorectal cancer have reduced overall survival. Currently, it is …

Chemotherapy is the major choice for the cancer treatment of early and advanced stages.
However, intrinsic or acquired drug resistance significantly restricts the clinical efficacy of …