[HTML][HTML] Metabolomics in antimicrobial drug discovery
R Aminov - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction In light of the ever-escalating problem of antimicrobial resistance, there is an
urgent need for the development of new antimicrobials. In this review, the role of …
urgent need for the development of new antimicrobials. In this review, the role of …
[HTML][HTML] The pharmacokinetic–pharmacodynamic modelling framework as a tool to predict drug resistance evolution
Pharmacokinetic–pharmacodynamic (PKPD) models, which describe how drug
concentrations change over time and how that affects pathogen growth, have proven highly …
concentrations change over time and how that affects pathogen growth, have proven highly …
[HTML][HTML] Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens
The success of antimicrobial treatment is threatened by the evolution of drug resistance.
Population genetic models are an important tool in mitigating that threat. However, most …
Population genetic models are an important tool in mitigating that threat. However, most …
A guide to enzyme kinetics in early drug discovery
B Srinivasan - The FEBS Journal, 2023 - Wiley Online Library
Drugs interact with their target of interest to bring about the desired phenotypic outcome that
results in disease alleviation. Traditionally, most lead optimization exercises were driven by …
results in disease alleviation. Traditionally, most lead optimization exercises were driven by …
[HTML][HTML] Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning
Organophosphorus (OP) compounds represent a serious health hazard worldwide. The
dominant mechanism of their action results from covalent inhibition of acetylcholinesterase …
dominant mechanism of their action results from covalent inhibition of acetylcholinesterase …
Assessing the relative importance of bacterial resistance, persistence and hyper-mutation for antibiotic treatment failure
To curb the rising threat of antimicrobial resistance, we need to understand the routes to
antimicrobial treatment failure. Bacteria can survive treatment by using both genetic and …
antimicrobial treatment failure. Bacteria can survive treatment by using both genetic and …
[HTML][HTML] Perspectives for systems biology in the management of tuberculosis
I Kontsevaya, C Lange… - European …, 2021 - Eur Respiratory Soc
Standardised management of tuberculosis may soon be replaced by individualised,
precision medicine-guided therapies informed with knowledge provided by the field of …
precision medicine-guided therapies informed with knowledge provided by the field of …
Semi-quantitatively predicting the residence time of three natural products on endothelin receptor A by peak profiling using the receptor functionalized macroporous …
P Li, B Shi, L Li, J Yin, Q Yao, T Yang, X Huang… - Journal of Analysis and …, 2023 - Springer
Drug–receptor interaction analysis has been broadly adopted as a tool for the evaluation of
the drug-like property. Nowadays, growing evidence has demonstrated that drug efficacy …
the drug-like property. Nowadays, growing evidence has demonstrated that drug efficacy …
Systems biology: current status and challenges
We put together a special issue on current approaches in systems biology with a focus on
mathematical modeling of metabolic networks. Mathematical models have increasingly been …
mathematical modeling of metabolic networks. Mathematical models have increasingly been …
[HTML][HTML] Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren's syndrome
Sjögren's syndrome is a chronic inflammatory autoimmune disease characterized by
diminished secretory function of the exocrine glands. Although extensive investigation has …
diminished secretory function of the exocrine glands. Although extensive investigation has …