The combination of chemotherapy, fluorouracil and cisplatin, and radiation has improved
outcome for patients with esophageal cancer. A randomized controlled trial confirmed a long …

Background: This study aimed to analyze the scientific outputs of esophageal and
esophagogastric junction (EGJ) cancer and construct a model to quantitatively and …

AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum
samples, its impact on p16-protein expression, and correlation with clinical and histological …

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is the second-most
frequently diagnosed cancer in Northeast Iran, often diagnosed in advanced stages. No …

Although caloric restriction (CR) has been shown to increase lifespan in various animal
models, the mechanisms underlying this phenomenon have not yet been revealed. We …

Background Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2
are considered to be essential G1 cell cycle regulatory genes whose loss of function is …

Epigenetic alteration of tumor suppression gene is one of the most significant indicators in
human esophageal squamous cell carcinoma (ESCC). In this study, we identified a novel …

Esophageal cancer is aggressive and has poor prognosis. Esophageal squamous cell
carcinoma (ESCC) is histologically the most prevalent type of esophageal cancer and …

CDKN2A is a tumor suppressor gene and is frequently inactivated in human cancers by
hypermethylation of its promoter. However, the role and diagnostic value of CDKN2A …

Esophageal cancer is ranked as the sixth most common cause of cancer death worldwide
and has a substantial effect on public health. In contrast to adenocarcinoma arising from …