Activating transcription in bacteria

DJ Lee, SD Minchin, SJW Busby - Annual review of microbiology, 2012 - annualreviews.org
Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in
order to activate transcription in response to growth signals or environmental cues …

AraC protein, regulation of the l-arabinose operon in Escherichia coli, and the light switch mechanism of AraC action

R Schleif - FEMS microbiology reviews, 2010 - academic.oup.com
This review covers the physiological aspects of regulation of the arabinose operon in
Escherichia coli and the physical and regulatory properties of the operon's controlling gene …

Regulation of the L-arabinose operon of Escherichia coli

R Schleif - Trends in genetics, 2000 - cell.com
Over forty years of research on the l-arabinose operon of Escherichia coli have provided
insights into the mechanism of positive regulation of gene activity. This research also …

The AraC transcriptional activators

RG Martin, JL Rosner - Current opinion in microbiology, 2001 - Elsevier
The AraC family of bacterial transcriptional activators regulate diverse genetic systems.
Recent X-ray diffraction studies show that the monomeric MarA and Rob activators bind to …

Structural basis for ligand-regulated oligomerization of AraC

SM Soisson, B MacDougall-Shackleton, R Schleif… - Science, 1997 - science.org
The crystal structure of the arabinose-binding and dimerization domain of the Escherchia
coli gene regulatory protein AraC was determined in the presence and absence of l …

Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA

HJ Kwon, MHJ Bennik, B Demple… - Nature structural …, 2000 - nature.com
Abstract The Escherichia coli Rob protein is a transcription factor belonging to the AraC/XylS
protein family that regulates genes involved in resistance to antibiotics, organic solvents and …

The transport and mediation mechanisms of the common sugars in Escherichia coli

Y Luo, T Zhang, H Wu - Biotechnology Advances, 2014 - Elsevier
Escherichia coli can uptake and utilize many common natural sugars to form biomass or
valuable target bio-products. Carbon catabolite repression (CCR) will occur and hamper the …

Quantitative Trait Loci for Refractoriness of Anopheles gambiae to Plasmodium cynomolgi B

L Zheng, AJ Cornel, R Wang, H Erfle, H Voss… - Science, 1997 - science.org
The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of
parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of …

AraC protein: a love–hate relationship

R Schleif - Bioessays, 2003 - Wiley Online Library
In the bacterium Escherichia coli, the AraC protein positively and negatively regulates
expression of the proteins required for the uptake and catabolism of the sugar L‐arabinose …

Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply

WF Liang, LY Cui, JY Cui, KW Yu, S Yang… - Metabolic …, 2017 - Elsevier
Acetyl-CoA is not only an important intermediate metabolite for cells but also a significant
precursor for production of industrially interesting metabolites. Methylobacterium extorquens …