Recent advances and perspectives on production of value-added organic acids through metabolic engineering
Organic acids are important consumable materials with a wide range of applications in the
food, biopolymer and chemical industries. The global consumer organic acids market is …
food, biopolymer and chemical industries. The global consumer organic acids market is …
DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …
scale, but some drawbacks still exist in this process, such as unstable intermediates …
Metabolic engineering of Pichia pastoris for malic acid production from methanol
F Guo, Z Dai, W Peng, S Zhang, J Zhou… - Biotechnology and …, 2021 - Wiley Online Library
The application of rational design in reallocating metabolic flux to accumulate desired
chemicals is always restricted by the native regulatory network. In this study, recombinant …
chemicals is always restricted by the native regulatory network. In this study, recombinant …
Microbial cell factories based on filamentous bacteria, yeasts, and fungi
Q Ding, C Ye - Microbial Cell Factories, 2023 - Springer
Background Advanced DNA synthesis, biosensor assembly, and genetic circuit
development in synthetic biology and metabolic engineering have reinforced the application …
development in synthetic biology and metabolic engineering have reinforced the application …
Engineering of unconventional yeast Yarrowia lipolytica for efficient succinic acid production from glycerol at low pH
Z Cui, C Gao, J Li, J Hou, CSK Lin, Q Qi - Metabolic engineering, 2017 - Elsevier
Yarrowia lipolytica is considered as a potential candidate for succinic acid production
because of its innate ability to accumulate citric acid cycle intermediates and its tolerance to …
because of its innate ability to accumulate citric acid cycle intermediates and its tolerance to …
MiYA, an efficient machine-learning workflow in conjunction with the YeastFab assembly strategy for combinatorial optimization of heterologous metabolic pathways in …
Facing boosting ability to construct combinatorial metabolic pathways, how to search the
metabolic sweet spot has become the rate-limiting step. We here reported an efficient …
metabolic sweet spot has become the rate-limiting step. We here reported an efficient …
Metabolic engineering of microorganisms for the production of natural compounds
Natural products have been attracting much interest around the world for their diverse
applications, especially in drug and food industries. Plants have been a major source of …
applications, especially in drug and food industries. Plants have been a major source of …
Combinatorial pathway optimization for streamlined metabolic engineering
Highlights•Combinatorial pathway optimization for microbial production is highlighted.•
Frequently applied methods for diversification are critically scrutinized.•Important heuristics …
Frequently applied methods for diversification are critically scrutinized.•Important heuristics …
Systematic Optimization of Limonene Production in Engineered Escherichia coli
J Wu, S Cheng, J Cao, J Qiao… - Journal of agricultural and …, 2019 - ACS Publications
Limonene, a cyclic monoterpene, is widely used in food and cosmetics industries as well as
in agriculture. In the work described herein, employing a systematic optimization strategy …
in agriculture. In the work described herein, employing a systematic optimization strategy …
Engineering Escherichia coli for malate production by integrating modular pathway characterization with CRISPRi‐guided multiplexed metabolic tuning
The application of rational design in reallocating metabolic flux to overproduce desired
chemicals is always restricted by the native regulatory network. Here, we demonstrated that …
chemicals is always restricted by the native regulatory network. Here, we demonstrated that …