With the mapping of the human genome having been completed, our ability to investigate
and ideally better understand the genetic basis of rheumatic diseases is advancing at a …

The association of HLA‐B27 with ankylosing spondylitis and other spondyloarthropathies
ranks among the strongest between any HLA antigen and a human disease. Yet, in spite of …

BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
can involve MHC-restricted presentation of a drug or its metabolites for T-cell activation. HLA …

Langerhans cells (LCs) are a subset of dendritic cells (DCs) that reside within epidermal and
mucosal tissue. Because of their location, LCs are potentially the first cells to encounter …

The human major histocompatibility complex (MHC) class I allele HLA-B27 bears a striking
association with the spondylolarthritic group of inflammatory arthritides, yet despite …

The reasons for the association of the human major histocompatibility complex protein HLA-
B27 with spondyloarthropathies are unknown. To uncover the underlying molecular causes …

The very strong association of human leukocyte antigen (HLA)‐B27 with spondyloarthritis
might be related to its peptide‐presenting properties. The natural polymorphism of this …

The association of human leukocyte antigen (HLA)‐B27 to ankylosing spondylitis is one of
the strongest between a major histocompatibility complex molecule and a disease. Yet, the …

HLA-B27 is a serologic specificity that encompasses 25 different alleles that encode 23
different products (proteins): HLA-B* 2701 to B* 2723. These alleles are also called …

Population and peptide specificity analyses and studies in transgenic rodents support a role
of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay …