[HTML][HTML] TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
[HTML][HTML] Molecular physiology of TRPV channels: controversies and future challenges
T Rosenbaum, LD Islas - Annual Review of Physiology, 2023 - annualreviews.org
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …
molecules that allow the detection of such signals include ion channels, which are proteins …
[HTML][HTML] Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …
conditionally conduct small and large cations. Such functional plasticity is presumably …
[HTML][HTML] Molecular basis for ligand modulation of a mammalian voltage-gated Ca2+ channel
The L-type voltage-gated Ca 2+(Ca v) channels are modulated by various compounds
exemplified by 1, 4-dihydropyridines (DHP), benzothiazepines (BTZ), and …
exemplified by 1, 4-dihydropyridines (DHP), benzothiazepines (BTZ), and …
Structure and gating mechanism of the transient receptor potential channel TRPV3
AK Singh, LL McGoldrick, AI Sobolevsky - Nature structural & molecular …, 2018 - nature.com
Transient receptor potential vanilloid subfamily member 3 (TRPV3) channel plays a crucial
role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with …
role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with …
[HTML][HTML] Structural mechanisms of TRPM7 activation and inhibition
KD Nadezhdin, L Correia, C Narangoda… - Nature …, 2023 - nature.com
The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …
balance of divalent cations that plays an essential role in embryonic development, immune …
[HTML][HTML] Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer
UM Demel, M Böger, S Yousefian… - The Journal of …, 2022 - Am Soc Clin Investig
Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-
regulated immune evasion mechanisms, we identified an evolutionarily conserved function …
regulated immune evasion mechanisms, we identified an evolutionarily conserved function …
Structural insights into TRPM8 inhibition and desensitization
MM Diver, Y Cheng, D Julius - Science, 2019 - science.org
The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of
environmental cold and an important target for treating pathological cold hypersensitivity …
environmental cold and an important target for treating pathological cold hypersensitivity …
Structures and gating mechanism of human TRPM2
INTRODUCTION Transient receptor potential (TRP) melastatin 2 (TRPM2) is a Ca2+-
permeable, nonselective cation channel implicated in the development of many …
permeable, nonselective cation channel implicated in the development of many …
[HTML][HTML] Molecular mechanism of TRPV2 channel modulation by cannabidiol
RA Pumroy, A Samanta, Y Liu, TET Hughes, S Zhao… - Elife, 2019 - elifesciences.org
Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal
development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non …
development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non …