Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and
cause neurological symptoms. Here we describe structural changes in cerebral small …

Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …

Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous
system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells …

Brain endothelial LDL receptor-related protein 1 (LRP1) is involved in the clearance of Aβ
peptides across the blood-brain barrier (BBB). Here we show that endothelial deficiency of …

Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling pathways play a
key role in various cell processes related to host immunity. The last few years have seen an …

Treating central nervous system (CNS) diseases is complicated by the incapability of
numerous therapeutics to cross the blood–brain barrier (BBB), mainly composed of brain …

Incontinentia pigmenti (IP) is an X-linked dominant genodermatosis. The disease is known
to be caused by recurrent deletion of exons 4–10 of the Inhibitor Of Nuclear Factor Kappa B …

In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme β-
hexosaminidase causes GM2 and other gangliosides to accumulate in neurons and triggers …