Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
Assembling living building blocks to engineer complex tissues
L Ouyang, JPK Armstrong… - Advanced Functional …, 2020 - Wiley Online Library
The great demand for tissue and organ grafts, compounded by an aging demographic and a
shortage of available donors, has driven the development of bioengineering approaches …
shortage of available donors, has driven the development of bioengineering approaches …
Characterization and evaluation of 3D printed microfluidic chip for cell processing
Microfluidics has found ubiquitous presence in biological applications such as tissue
spheroid fabrication and pharmacology investigation. The increasing prevalence and …
spheroid fabrication and pharmacology investigation. The increasing prevalence and …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
Pumps for microfluidic cell culture
CK Byun, K Abi‐Samra, YK Cho, S Takayama - Electrophoresis, 2014 - Wiley Online Library
In comparison to traditional in vitro cell culture in Petri dishes or well plates, cell culture in
microfluidic‐based devices enables better control over chemical and physical environments …
microfluidic‐based devices enables better control over chemical and physical environments …
A review of manufacturing capabilities of cell spheroid generation technologies and future development
D Liu, S Chen, M Win Naing - Biotechnology and …, 2021 - Wiley Online Library
Spheroid culture provides cells with a three‐dimensional environment that can better mimic
physiological conditions compared to monolayer culture. Technologies involved in the …
physiological conditions compared to monolayer culture. Technologies involved in the …
High-throughput cancer cell sphere formation for characterizing the efficacy of photo dynamic therapy in 3D cell cultures
Photodynamic therapy (PDT), wherein light sensitive non-toxic agents are locally and
selectively activated using light, has emerged as an appealing alternative to traditional …
selectively activated using light, has emerged as an appealing alternative to traditional …
Advances of microfluidics in biomedical engineering
As an enabling technique, microfluidic systems have developed rapidly in recent years to
emerge as a powerful tool in the field of biomedical engineering. Microfluidics enables …
emerge as a powerful tool in the field of biomedical engineering. Microfluidics enables …
Advanced biomedical applications based on emerging 3D cell culturing platforms
It is of great value to develop reliable in vitro models for cell biology and toxicology.
However, ethical issues and the decreasing number of donors restrict the further use of …
However, ethical issues and the decreasing number of donors restrict the further use of …
Open-source, 3D-printed peristaltic pumps for small volume point-of-care liquid handling
Microfluidic technologies are frequently employed as point-of-care diagnostic tools for
improving time-to-diagnosis and improving patient outcomes in clinical settings. These …
improving time-to-diagnosis and improving patient outcomes in clinical settings. These …