Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

RS Vardanyan, VJ Hruby - Future medicinal chemistry, 2014 - Taylor & Francis
Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain
for many years. In this review, we outline the structural and corresponding synthetic …

Endogenous opiates and behavior: 2005

RJ Bodnar, GE Klein - Peptides, 2006 - Elsevier
This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

A photochromic agonist for μ‐opioid receptors

M Schönberger, D Trauner - Angewandte Chemie International …, 2014 - Wiley Online Library
Opioid receptors (ORs) are widely distributed in the brain, the spinal cord, and the digestive
tract and play an important role in nociception. All known ORs are G‐protein‐coupled …

Fentanyl analogs: structure-activity-relationship study

S Vuckovic, M Prostran, M Ivanovic… - Current medicinal …, 2009 - ingentaconnect.com
Fentanyl is the prototype of the 4-anilidopiperidine class of synthetic opioid analgesics. This
study was aimed to review the structure-activity-relationship (SAR) of fentanyl analogs …

[PDF][PDF] Dark classics in chemical neuroscience: comprehensive study on the biochemical mechanisms and clinical implications of opioid analgesics

F Khamooshi, S Doraji-Bonjar… - Chemical …, 2023 - researchgate.net
In terms of pharmaceutical grouping, opioids are natural and synthetic substances derived
and simulated from opium [1, 2] which can activate the neurological system by a connection …

Development of potent μ and δ opioid agonists with high lipophilicity

YS Lee, V Kulkarani, SM Cowell, S Ma… - Journal of medicinal …, 2011 - ACS Publications
An SAR study on the Dmt-substituted enkephalin-like tetrapeptide with a N-phenyl-N-
piperidin-4-ylpropionamide moiety at the C-terminal was performed and has resulted in …

Photocontrol over molecular shape: synthesis and photochemical evaluation of glycoazobenzene macrocycles

G Despras, J Hain, SO Jaeschke - Chemistry–A European …, 2017 - Wiley Online Library
Reversible shape switching due to external stimuli is an attractive property for the control of
molecular features. Hence, we aimed at macrocycles to investigate photoswitching of …

The spectroscopic (FT-IR, FT-Raman, l3C, 1H NMR and UV) and NBO analyses of 4-bromo-1-(ethoxycarbonyl) piperidine-4-carboxylic acid

VD Vitnik, ŽJ Vitnik - Spectrochimica Acta Part A: Molecular and …, 2015 - Elsevier
In this work, we will report a combined experimental and theoretical study on molecular and
vibrational structure of 4-bromo-1-(ethoxycarbonyl) piperidine-4-carboxylic acid (BEPA) …

Development of novel enkephalin analogues that have enhanced opioid activities at both μ and δ opioid receptors

YS Lee, R Petrov, CK Park, S Ma, P Davis… - Journal of medicinal …, 2007 - ACS Publications
Enkephalin analogues with a 4-anilidopiperidine scaffold have been designed and
synthesized to achieve therapeutic benefit for the treatment of pain due to mixed μ and δ …

Topical fentanyl in a randomized, double-blind study in patients with corneal damage

C Zöllner, S Mousa, A Klinger, M Förster… - The Clinical journal of …, 2008 - journals.lww.com
Objectives Corneal damage causes severe pain. This study investigated whether peripheral
opioid receptors are present in the human cornea and assessed the efficacy of topical …