The prevention and treatment of human cytomegalovirus (HCMV) infections is based on the
use of antiviral agents that currently target the viral DNA polymerase and that may cause …

Human herpesviruses are large double-stranded DNA viruses belonging to the
Herpesviridae family. These viruses have the ability to establish lifelong latency into the host …

Technical advancements can enhance the accurate and timely genotypic detection of drug
resistance. Antivirals undergoing clinical trial offer the prospect of new viral targets and drug …

Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in
allogeneic hematopoietic stem cell transplant recipients. The significant clinical impact of …

Diagnostic mutations in the cytomegalovirus UL97 kinase gene are used to assess the level
of associated ganciclovir resistance and therapeutic options. The best-known mutations at …

Cytomegalovirus (CMV) infections may increase morbidity and mortality in
immunocompromised patients. Until recently, standard antiviral drugs against CMV were …

The appearance of drug-resistant mutations in UL54 DNA polymerase and UL97 kinase
genes is problematic for the treatment of human cytomegalovirus (HCMV) diseases. During …

The discovery of the nucleoside analogue, acyclovir, represented a milestone in the
management of infections caused by herpes simplex virus and varicella-zoster virus …

Background Human cytomegalovirus (HCMV) infections remain a major problem in
immunocompromised patients. Three antiviral agents, ganciclovir (GCV), foscarnet (FOS) …

Cytomegalovirus (CMV) infection is a serious complication in hematopoietic cell
transplantation (HCT) recipients. Drug-resistant strains make it more challenging to treat …