Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …

Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms
and testing interventions and therapeutics. For disorders such as Alzheimer's disease in …

In the mitochondrial outer membrane, α-helical transmembrane proteins play critical roles in
cytoplasmic-mitochondrial communication. Using genome-wide CRISPR screens, we …

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

Summary iPSC-derived microglia offer a powerful tool to study microglial homeostasis and
disease-associated inflammatory responses. Yet, microglia are highly sensitive to their …

Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …

The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

This review is focused on several psychiatric disorders in which cognitive impairment is a
major component of the disease, influencing life quality. There are plenty of data proving that …

Importance Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide
association studies have identified more than 20 AD risk genes. The precise mechanism …