Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Colorectal carcinoma: a general overview and future perspectives in colorectal cancer

I Mármol, C Sánchez-de-Diego… - International journal of …, 2017 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …

Sample preparation and imaging of exosomes by transmission electron microscopy

MK Jung, JY Mun - Journal of visualized experiments: JoVE, 2018 - pmc.ncbi.nlm.nih.gov
Exosomes are nano-sized extracellular vesicles secreted by body fluids and are known to
represent the characteristics of cells that secrete them. The contents and morphology of the …

Overview upon miR-21 in lung cancer: focus on NSCLC

C Bica-Pop, R Cojocneanu-Petric, L Magdo… - Cellular and Molecular …, 2018 - Springer
Considering the high mortality rate encountered in lung cancer, there is a strong need to
explore new biomarkers for early diagnosis and also improved therapeutic targets to …

New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Trends in research on exosomes in cancer progression and anticancer therapy

D Sinha, S Roy, P Saha, N Chatterjee, A Bishayee - Cancers, 2021 - mdpi.com
Simple Summary Intensive research in the field of cancer biology has discovered a unique
mode of interplay between cells via extracellular bioactive vesicles called exosomes …

The new era of nanotechnology, an alternative to change cancer treatment

A Jurj, C Braicu, LA Pop, C Tomuleasa… - Drug design …, 2017 - Taylor & Francis
In the last few years, nanostructures have gained considerable interest for the safe delivery
of therapeutic agents. Several therapeutic approaches have been reported, such as …

microRNA‐16‐5p‐containing exosomes derived from bone marrow‐derived mesenchymal stem cells inhibit proliferation, migration, and invasion, while promoting …

Y Xu, L Shen, F Li, J Yang, X Wan… - Journal of cellular …, 2019 - Wiley Online Library
Colorectal cancer (CRC) is a form of cancer developing from either the colon or rectum.
Nowadays, research supports the functionality of exosome expressing microRNAs (miRNAs) …