Research in the last decade has substantially advanced our understanding of the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). However …

While risk scores are invaluable tools for adapted preventive strategies, a significant gap
exists between predicted and actual event rates. Additional tools to further stratify the risk of …

Importance If we assume that women and men exhibit variations of the same fundamental
vascular physiology, then conventional analyses of subclinical measures would suggest that …

Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and
arterial diameter change with each heartbeat. In addition to the passive mechanical …

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic
mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment …

Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …

Background: Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). Objectives: This …

Background—Inorganic nitrate (NO3−), abundant in certain vegetables, is converted to
nitrite by bacteria in the oral cavity. Nitrite can be converted to nitric oxide in the setting of …

Background Tissue Doppler index E/è is used clinically and in multidisciplinary research for
estimation of left ventricular filling pressure (LVFP) and diastolic dysfunction (DD)/heart …

Due to the cyclic function of the human heart, pressure and flow in the circulation are
pulsatile rather than continuous. Addressing pulsatile haemodynamics starts with the most …