Cellular and molecular immune response to chikungunya virus infection

ISB Tanabe, ELL Tanabe, EC Santos… - Frontiers in cellular …, 2018 - frontiersin.org
Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a
disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the …

Beyond fever and pain: diagnostic methods for chikungunya virus

MS Natrajan, A Rojas, JJ Waggoner - Journal of clinical …, 2019 - Am Soc Microbiol
Chikungunya virus (CHIKV) is an alphavirus that is primarily transmitted by Aedes species
mosquitoes. Though reports of an illness consistent with chikungunya date back over 200 …

Laboratory diagnosis of chikungunya virus infections and commercial sources for diagnostic assays

BW Johnson, BJ Russell… - The Journal of infectious …, 2016 - academic.oup.com
Detection of chikungunya virus (CHIKV) or viral RNA is the primary laboratory test used to
diagnose infection in serum collected< 6 days after onset of illness. Two real-time reverse …

Diagnostic accuracy of serological tests for the diagnosis of Chikungunya virus infection: A systematic review and meta-analysis

A Andrew, TN Navien, TS Yeoh… - PLoS Neglected …, 2022 - journals.plos.org
Background Chikungunya virus (CHIKV) causes febrile illnesses and has always been
misdiagnosed as other viral infections, such as dengue and Zika; thus, a laboratory test is …

The neutralizing role of IgM during early Chikungunya virus infection

CL Chua, IC Sam, CW Chiam, YF Chan - PloS one, 2017 - journals.plos.org
The antibody isotype IgM appears earlier than IgG, within days of onset of symptoms, and is
important during the early stages of the adaptive immune response. Little is known about the …

Risk factors for infection with chikungunya and Zika viruses in southern Puerto Rico: a community-based cross-sectional seroprevalence survey

LE Adams, L Sánchez-González… - PLOS Neglected …, 2022 - journals.plos.org
Chikungunya virus (CHIKV) caused a large outbreak in Puerto Rico in 2014, followed by a
Zika virus (ZIKV) outbreak in 2016. Communities Organized for the Prevention of …

Analysis of a routinely used commercial anti-chikungunya IgM ELISA reveals cross-reactivities with dengue in Brazil: a new challenge for differential diagnosis?

MRQ Lima, RC de Lima, EL de Azeredo… - Diagnostics, 2021 - mdpi.com
In Brazil, chikungunya emerged in 2014, and by 2016, co-circulated with other arbovirosis,
such as dengue and zika. ELISAs (Enzyme-Linked Immunosorbent Assays) are the most …

Reliable serological diagnostic tests for arboviruses: feasible or utopia?

K Kerkhof, F Falconi-Agapito, M Van Esbroeck… - Trends in …, 2020 - cell.com
Infections with arthropod-borne viruses are increasing globally as a result of climate and
demographic changes, global dispersion of insect vectors, and increased air travel. The …

GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

L Pezzi, CB Reusken, SC Weaver, JF Drexler, M Busch… - Antiviral research, 2019 - Elsevier
Abstract The GloPID-R (Global Research Collaboration for Infectious Disease
Preparedness) Chikungunya (CHIKV), O'nyong-nyong (ONNV) and Mayaro virus (MAYV) …

Reliable serological testing for the diagnosis of emerging infectious diseases

C Ohst, S Saschenbrecker, K Stiba… - Dengue and zika …, 2018 - Springer
Climate change, increased urbanization and international travel have facilitated the spread
of mosquito vectors and the viral species they carry. Zika virus (ZIKV) is currently spreading …