Heart failure is a global health burden responsible for high morbidity and mortality with a
prevalence of greater than 60 million individuals worldwide. One of the major causes of …

Myofibrils are the intracellular structures formed by actin and myosin filaments. They are
paracrystalline contractile cables with unusually well-defined dimensions. The sliding of …

Background: ALPK3 encodes α-kinase 3, a muscle-specific protein of unknown function.
ALPK3 loss-of-function variants cause cardiomyopathy with distinctive clinical …

Hypertrophic cardiomyopathy (HCM) is a genetic disease of the myocardium characterized
by a hypertrophic left ventricle with a preserved or increased ejection fraction. Cardiac …

Background Copy number variation sequencing (CNV-seq) was proven to be a highly
effective tool in studying of chromosomal copy number variations (CNVs) in prenatal …

Although opioids are necessary for the treatment of acute pain, cancer pain, and palliative
care, opioid abuse is a serious threat to society. Heroin (Diacetylmorphine) is the most …

Background: Heart failure (HF) is the most common cardiovascular diseases and the leading
cause of cardiovascular diseases related deaths. Increasing molecular targets have been …

Turner Syndrome (TS) is a rare cytogenetic disorder caused by the complete loss or
structural variation of the second sex chromosome. The most common cause of early …

Motivation Gene functional enrichment analysis represents one of the most popular
bioinformatics methods for annotating the pathways and function categories of a given gene …

Evolutionary novelties entail the origin of morphologies that enable new functions. These
features can arise through changes to gene function and regulation. One key novelty is the …