Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …

In the mammalian lung, an apparently homogenous mesh of capillary vessels surrounds
each alveolus, forming the vast respiratory surface across which oxygen transfers to the …

Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells …

Engineering hierarchical vasculatures is critical for creating implantable functional thick
tissues. Current approaches focus on fabricating mesoscale vessels for implantation or …

The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that
when defective results in congenital heart disease (CHD). With current therapies, more than …

Molecular mechanisms of ovarian aging and female age-related fertility decline remain
unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and …

Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

INTRODUCTION The brains of extant animals have evolved over hundreds of millions of
years from simple circuits. Cell types diversified, connections elaborated, and new brain …