A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Restorative cell-based and pharmacological therapies for experimental stroke substantially
improve functional outcome. These therapies target several types of parenchymal cells …

Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by
neoplastic stem cells that retain partial yet abnormal differentiation potential. Here, we show …

During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

The distinctive differentiated states of the CD4+ T helper cells are determined by the set of
transcription factors and the genes transcribed by the transcription factors. In vitro induction …

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …

Highlights•Astrocytes play crucial roles in establishing neural circuits during
development.•The onset of astrogenesis is temporally regulated.•Extrinsic cues and intrinsic …

Cellular quiescence, defined as reversible growth/proliferation arrest, is thought to represent
a homogenous state induced by diverse anti-mitogenic signals. We used transcriptional …

GABAergic cortical interneurons underlie the complexity of neural circuits and are
particularly numerous and diverse in humans. In rodents, cortical interneurons originate in …

The mechanisms controlling the transition from neurogenesis to gliogenesis in the
vertebrate CNS are incompletely understood. We identified a family of transcription factors …