Food strategies are currently used to improve inflammation and oxidative stress conditions
in chronic pain which contributes to a better quality of life for patients. The main purpose of …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Although painful stimuli elicit defensive responses including escape behavior for survival,
starved animals often prioritize feeding over escape even in a noxious environment. This …

The effective prevention of postoperative cognitive dysfunction (POCD) needs to be
explored, and the effect of preoperative pain on POCD remains unclear. We established a …

The opioid epidemic has plagued the United States with high levels of abuse and poor
quality of life for chronic pain patients requiring continuous use of opioids. New drug …

Objectives Feeding behavior is known to have potential to alleviate pain. We recently
demonstrated that both 24 h fasting and 2 h refeeding (food intake after 24 h fasting) induce …

Feeding behaviors are closely associated with chronic pain in adult rodents. Our recent
study revealed that 2 h refeeding after 24 h fasting (ie, refeeding) attenuates pain behavior …

Opioids, which are widely used for the treatment of chronic pain, have an analgesic effect by
mainly activating mu-opioid receptor (MOR). Paradoxically, a high dose of naloxone, non …

Aim Tryptophan (TRP), an essential amino acid, undergoes catabolism through various
pathways. Notably, the kynurenine pathway (KP), constituting one of these pathways …

Objective Fasting regimens can promote health, mitigate chronic immunological disorders,
and improve age-related pathophysiological parameters in animals and humans. Several …