Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

The adrenal gland is a source of sex steroid precursors, and its activity is particularly
relevant during fetal development and adrenarche. Following puberty, the synthesis of …

Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain,
fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid
structures and measuring steroid concentrations in body fluids. The molecular biology …

Context Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S)
associated with the development of a functional adrenal zona reticularis. Clinical features of …

Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is
implicated in the development and progression of castration resistant prostate cancer …

Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …

Bile acids (BAs) and glucocorticoids are steroid hormones derived from cholesterol that are
important signaling molecules in humans and other vertebrates. Hydroxysteroid …