Use of V (D) J recombination excision circles to identify T-and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies
F Serana, M Chiarini, C Zanotti, A Sottini… - Journal of translational …, 2013 - Springer
T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles
(KRECs) are circular DNA segments generated in T and B cells during their maturation in …
(KRECs) are circular DNA segments generated in T and B cells during their maturation in …
B-cell reconstitution for SCID: should a conditioning regimen be used in SCID treatment?
E Haddad, S Leroy, RH Buckley - Journal of Allergy and Clinical …, 2013 - Elsevier
Bone marrow transplantation has resulted in life-saving sustained T-cell reconstitution in
many infants with severe combined immunodeficiency (SCID), but correction of B-cell …
many infants with severe combined immunodeficiency (SCID), but correction of B-cell …
Long-term immune reconstitution and outcome after HLA-nonidentical T-cell–depleted bone marrow transplantation for severe combined immunodeficiency: a …
We have performed a retrospective analysis of the development of T-and B-cell functions
after HLA-nonidentical T-cell–depleted bone marrow transplantation (BMT) performed in …
after HLA-nonidentical T-cell–depleted bone marrow transplantation (BMT) performed in …
Long-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency
B Reinhardt, O Habib, KL Shaw… - Blood, The Journal …, 2021 - ashpublications.org
Patients lacking functional adenosine deaminase activity have severe combined
immunodeficiency (ADA SCID), which can be treated with ADA enzyme replacement therapy …
immunodeficiency (ADA SCID), which can be treated with ADA enzyme replacement therapy …
T-cell recovery in adults and children following umbilical cord blood transplantation
AK Klein, DD Patel, ME Gooding… - Biology of blood and …, 2001 - Elsevier
T-cell reconstitution following allogeneic stem cell transplantation may involve thymic
education of donor-derived precursors or peripheral expansion of mature T cells transferred …
education of donor-derived precursors or peripheral expansion of mature T cells transferred …
Systematic evidence review of newborn screening and treatment of severe combined immunodeficiency
EA Lipstein, S Vorono, MF Browning, NS Green… - …, 2010 - publications.aap.org
CONTEXT: Severe combined immunodeficiency (SCID) is a group of disorders that leads to
early childhood death as a result of severe infections. Recent research has addressed …
early childhood death as a result of severe infections. Recent research has addressed …
Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via in utero or postnatal transfer
BR Blazar, PA Taylor, R McElmurry… - Blood, The Journal …, 1998 - ashpublications.org
Although in utero transplantation (IUT) has been shown to be effective in treating human
severe combined immune deficiency (SCID), the relative merit of IUT as compared with …
severe combined immune deficiency (SCID), the relative merit of IUT as compared with …
Influence of severe combined immunodeficiency phenotype on the outcome of HLA non-identical, T-cell–depleted bone marrow transplantationA retrospective …
Y Bertrand, P Landais, W Friedrich, B Gerritsen… - The Journal of …, 1999 - Elsevier
We analyzed the outcomes of 214 HLA non-identical T-cell–depleted bone marrow
transplantations (BMTs), performed in 178 consecutive patients for treatment of severe …
transplantations (BMTs), performed in 178 consecutive patients for treatment of severe …
Post-transplantation B cell function in different molecular types of SCID
RH Buckley, CM Win, BK Moser, RE Parrott… - Journal of clinical …, 2013 - Springer
Purpose Severe combined immunodeficiency (SCID) is a syndrome of diverse genetic
cause characterized by profound deficiencies of T, B and sometimes NK cell function. Non …
cause characterized by profound deficiencies of T, B and sometimes NK cell function. Non …
Long-term chimerism and B-cell function after bone marrow transplantation in patients with severe combined immunodeficiency with B cells: a single-center study of …
E Haddad, FL Deist, P Aucouturier… - Blood, The Journal …, 1999 - ashpublications.org
We retrospectively analyzed the B-cell function and leukocyte chimerism of 22 patients with
severe combined immunodeficiency with B cells (B+ SCID) who survived more than 2 years …
severe combined immunodeficiency with B cells (B+ SCID) who survived more than 2 years …