During recent years, small molecules containing five-member heterocyclic moieties have
become the subject of considerable growing interest for designing new antitumor agents …

Introduction: Four isomeric structures of thiadiazole motifs have outstanding
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …

1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

The 1, 3, 4-thiadiazole nucleus has attracted the attention of medicinal chemists during the
last decades due to its multiple pharmacological activities, such as antiviral, anticancer …

Background: Due to the importance of 1, 3, 4-thiadiazoles and phthalimides in anticancer
agents, a novel series of 1, 3, 4-thiadiazole-phthalimide system have been synthesized and …

Background: α-Glucosidase inhibitors have occupied a significant position in the treatment
of type 2 diabetes. In this respect, the development of novel and efficient non-sugar-based …

Five membered heterocyclic rings possessing a mixture of different heteroatoms like S, N, O,
etc. not only possess interesting chemical properties but also have a myriad number of …

Abstract Levofloxacin, the optical S‐(‐) isomer of ofloxacin, is a broad‐spectrum antibacterial
agent widely used to control various infections caused by Gram‐positive and Gram‐negative …

Thiadiazole is a heterocyclic molecule made up of one sulphur atom, two nitrogen atoms,
and two double-bonded 5-membered ring systems. Heterocyclic compounds having …

We report a solvent-free synthesis of novel 1, 3, 4, 5-tetrasubstituted pyrazoles and
investigate their inhibitory activity against soybean 15-lipoxygenase. It was revealed that all …