Posttraumatic stress disorder (PTSD) is characterized mainly by symptoms of re-
experiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic …

This review describes the latest developments in our understanding of how the serotonergic
system modulates Pavlovian fear conditioning, fear expression and fear extinction. These …

Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of a
spectrum of anxiety disorders, yet paradoxically they may increase symptoms of anxiety …

Although often referred to as a hunger hormone, recent evidence highlights a
neuroprotective function of acylated ghrelin (AG) and a substantial role in the regulation of …

Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT)
reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders …

Activation of neurons in the bed nucleus of the stria terminalis (BNST) plays a critical role in
stress and anxiety-related behaviors. Previously, we have shown that serotonin (5-HT) can …

Conditioned fear plays a key role in anxiety disorders as well as depression and other
neuropsychiatric conditions. Understanding how neuromodulators drive the associated …

Mirtazapine is an antidepressant with a unique mechanism of action and has been
categorized as a Noradrenergic and Specific Serotonergic Antidepressant (NaSSA) …

Rationale Selective serotonin reuptake inhibitors (SSRIs) are considered first-line
medication for anxiety-like disorders such as panic disorder, generalized anxiety disorder …

Rationale The majority of psychoactive compounds, including antidepressants in clinical
practice, were discovered largely by serendipity. The underlying neuropharmacological …