Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Aging is associated with progressive changes in total and regional fat distribution that have
negative health consequences. Indeed, a preferential increase in abdominal fat, in particular …

Background—The risk of heart failure in type 2 diabetes mellitus is greater than can be
accounted for by hypertension and coronary artery disease. Rodent studies indicate that in …

Obesity is a well-known risk factor for the development of type 2 diabetes mellitus and
cardiovascular disease. Importantly, obesity is not only associated with lipid accumulation in …

Background—The mechanisms of right ventricular (RV) failure in pulmonary arterial
hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have …

Obesity and insulin resistance are associated with ectopic lipid deposition in multiple
tissues, including the heart. Excess lipid may be stored as triglycerides, but are also shunted …

At first glance, obesity, the metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM),
cardiovascular disease (CVD), and non-alcoholic fatty liver disease (NAFLD) and non …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Obesity is a major risk factor for heart disease. In the face of obesity's growing prevalence, it
is important for physicians to be aware of emerging research of novel mechanisms through …

Abstract Context and Objective: Ectopic fat accumulation within and around the myocardial
wall has been implicated in the pathogenesis of heart disease in obesity. We evaluated …