Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
Interleukin-1 and related cytokines in the regulation of inflammation and immunity
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …
the growing understanding of its context-dependent roles and advances in the clinic. Recent …
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
[HTML][HTML] The interleukin-1 family: back to the future
C Garlanda, CA Dinarello, A Mantovani - Immunity, 2013 - cell.com
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …
The family of the interleukin‐1 receptors
D Boraschi, P Italiani, S Weil… - Immunological reviews, 2018 - Wiley Online Library
The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …
The interleukin (IL)-1 cytokine family–Balance between agonists and antagonists in inflammatory diseases
Abstract The interleukin (IL)-1 family of cytokines comprises 11 members, including 7 pro-
inflammatory agonists (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) and 4 defined or …
inflammatory agonists (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) and 4 defined or …
Suppression of inflammation and acquired immunity by IL‐37
G Cavalli, CA Dinarello - Immunological reviews, 2018 - Wiley Online Library
IL‐37 is a unique member of the IL‐1 family of cytokines, which functions as a natural
suppressor of inflammatory and immune responses. Immune and non‐immune cells …
suppressor of inflammatory and immune responses. Immune and non‐immune cells …
Antimicrobial activity of anthocyanins and catechins against foodborne pathogens Escherichia coli and Salmonella
The main foodborne pathogens are Norovirus, Enteric parasites, bacteria and fungi.
Foodborne diseases can lead to high morbidity and mortality and result in huge economic …
Foodborne diseases can lead to high morbidity and mortality and result in huge economic …
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
CA Dinarello - Blood, The Journal of the American Society of …, 2011 - ashpublications.org
More than any other cytokine family, the IL-1 family of ligands and receptors is primarily
associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor …
associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor …
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
CA Nold-Petry, CY Lo, I Rudloff, KD Elgass, S Li… - Nature …, 2015 - nature.com
Abstract Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan
members of the IL-1 ligand family and IL-1 receptor family, respectively. Here we …
members of the IL-1 ligand family and IL-1 receptor family, respectively. Here we …