GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …

Growth and differentiation factor 15 (GDF-15) was discovered as a member of the
transforming growth factor β (TGF-β) superfamily and the serum level of GDF-15 was …

Background Although growth differentiation factor 15 (GDF15) is known to increase with
disease and is associated with low physical performance, the role of GDF15 in normal …

Abstract Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Its plasma
levels increase during aging and acute illness. In older Patients and age-matched Controls …

Introduction The elderly population is increasing worldwide and in Chile, it is expected to
grow rapidly. The World Health Organization (WHO) ICOPE guideline (Integrated Care for …

Low lymphocyte count, as a marker of inflammation and immunosuppression, may be useful
for identifying frail patients. In this work, we aimed to evaluate the association between low …

Background/objectives Subclinical cardiovascular disease (CVD) is cross-sectionally
associated with frailty, but the relationship between subclinical CVD and incident frailty has …

Background and aims The predictive value of growth differentiation factor-15 (GDF-15) for
individual cardiovascular outcomes remained controversial in patients with coronary artery …

Background: Frailty is an important outcome predictor in patients with aortic stenosis who
are candidates for transcatheter or surgical aortic valve replacement (AVR) …

Background Growth differentiation factor 15 (GDF15) has been associated with several age-
related disorders, but its associations with functional abilities in community-dwelling older …