Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Background: Chronic kidney disease and type 2 diabetes are independently associated with
heart failure (HF), a leading cause of morbidity and mortality. In the FIDELIO-DKD …

The new guidelines classify heart failure (HF) into three subgroups based on the ejection
fraction (EF): HF with reduced EF (HFrEF), HF with mid-range EF (HFmrEF), and HF with …

Aldosterone's role in the kidney and its pathophysiologic actions in hypertension are well
known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other …

Currently, the assessment of left ventricular ejection fraction (LVEF) is the cornerstone of the
classification of patients with heart failure (HF). The mid‐range LVEF (HFmrEF) category …

Aldosterone binds to the mineralocorticoid receptor (NR3C2), a transcription factor of the
nuclear receptor family, present in the kidney and in various other non‐epithelial cells …

Aims The study sought to comprehensively investigate the effect of heart failure (HF)
pharmacotherapies in patients with HF with mildly reduced ejection fraction (HFmrEF). In the …

Abstract Chronic Kidney Disease (CKD) is a major health problem characterized by kidney
dysfunction with progressive segmental glomerulosclerosis to end-stage renal disease …

Background: The number of heart failure with preserved ejection fraction (HFpEF) patients is
increasing year by year, yet all western medicines currently used for heart failure have been …

As myocardial fibrosis might be an important contributor to the association of diabetes
mellitus with left ventricular (LV) dysfunction and chronic heart failure (HF), we investigated …