Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Summary H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments.
They mainly harbor H3. 3K27M mutations resulting in H3K27me3 reduction. Integrated …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

In 2021 the World Health Organization published the fifth and latest version of the Central
Nervous System tumors classification, which incorporates and summarizes a long list of …

Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …

With technological advancements, radiotherapy (RT) has become an effective non-surgical
treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control …

Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

Abstract Background and Aims Poor response to ionizing radiation (IR) due to resistance
remains a clinical challenge. Altered metabolism represents a defining characteristic of …