Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Aptamers are short single-stranded DNA or RNA oligonucleotides that can selectively bind
to small molecular ligands or protein targets with high affinity and specificity, by acquiring …

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major
constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …

Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …

The discovery and identification of biomarkers promote the rational and fast development of
medical diagnosis and therapeutics. Clinically, the application of ideal biomarkers still is …