Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted …
M Liao, R Qin, W Huang, HP Zhu, F Peng… - Journal of Hematology & …, 2022 - Springer
Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …
[HTML][HTML] FOXO signaling pathways as therapeutic targets in cancer
Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …
Pathophysiology of primary open-angle glaucoma from a neuroinflammatory and neurotoxicity perspective: a review of the literature
K Evangelho, M Mogilevskaya… - International …, 2019 - Springer
Purpose Glaucoma is the leading cause of blindness in humans, affecting 2% of the
population. This disorder can be classified into various types including primary, secondary …
population. This disorder can be classified into various types including primary, secondary …
Artemisinin inhibits the migration and invasion in uveal melanoma via inhibition of the PI3K/AKT/mTOR signaling pathway
M Farhan, M Silva, X Xingan, Z Zhou… - … medicine and cellular …, 2021 - Wiley Online Library
Uveal melanoma is the most common primary ocular neoplasm in adults, with many patients
ending up developing liver metastasis and facing a significant reduction of their life …
ending up developing liver metastasis and facing a significant reduction of their life …
The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development
Autophagy is a highly conserved intracellular degradation process that plays a crucial role in
cell survival and stress reactions as well as in cancer development and metastasis …
cell survival and stress reactions as well as in cancer development and metastasis …
[HTML][HTML] Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish
ZL Chen, C Guo, YY Zou, C Feng, DX Yang… - Experimental …, 2023 - Elsevier
Sarcopenia is a common skeletal muscle degenerative disease characterized by decreased
skeletal muscle mass and mitochondrial dysfunction that involves microRNAs (miR) as …
skeletal muscle mass and mitochondrial dysfunction that involves microRNAs (miR) as …
Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway
X Zhang, L Wang, L Peng, X Tian, X Qiu… - Journal of Cellular …, 2019 - Wiley Online Library
The damage of vascular endothelial cells induced by oxidative stress plays an important role
in the pathogenesis of atherosclerosis. Dihydromyricetin (DMY) is considered as a natural …
in the pathogenesis of atherosclerosis. Dihydromyricetin (DMY) is considered as a natural …
ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway
C Cui, S Han, X Shen, H He, Y Chen, J Zhao… - Cell and tissue …, 2020 - Springer
Immunoglobulin superfamily containing leucine-rich repeat (Islr) contains an Ig-like domain,
an LRR motif, and a transmembrane domain and is highly expressed in various chicken …
an LRR motif, and a transmembrane domain and is highly expressed in various chicken …
[HTML][HTML] Acteoside protects retinal ganglion cells from experimental glaucoma by activating the PI3K/AKT signaling pathway via caveolin 1 upregulation
X Xi, Q Chen, J Ma, X Wang, Y Xia, X Wen… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Glaucoma is the second leading cause of blindness in the world and is
characterized by optic neuropathy and degeneration of retinal ganglion cells (RGCs). Our …
characterized by optic neuropathy and degeneration of retinal ganglion cells (RGCs). Our …
GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are among the
most common morbidities affecting extremely premature infants who receive oxygen …
most common morbidities affecting extremely premature infants who receive oxygen …