The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Faithful chromosome segregation requires robust, load-bearing attachments of
chromosomes to the mitotic spindle, a function accomplished by large macromolecular …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

The efficacy of current antimitotic cancer drugs is limited by toxicity in highly proliferative
healthy tissues. A cancer-specific dependency on the microtubule motor protein KIF18A …

Cytoplasmic Dynein 1, or Dynein, is a microtubule minus end–directed motor. Dynein
motility requires Dynactin and a family of activating adaptors that stabilize the Dynein …

Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Accurate chromosome segregation in mitosis depends on multiprotein structures called
kinetochores that are built on the centromeric region of sister chromatids and serve to …

The spindle assembly checkpoint (SAC) is a cellular surveillance mechanism that functions
to ensure accurate chromosome segregation during mitosis. Macromolecular complexes …