Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …

Microsatellite instability (MSI), which is caused by deficiency of the DNA mismatch repair
(MMR) system, is the molecular abnormality observed in tumors associated with Lynch …

Succinate dehydrogenase (SDH) is a conserved effector of cellular metabolism and energy
production, and loss of SDH function is a driver mechanism in several cancers. SDH …

The development of colorectal cancer (CRC) can be influenced by genetic factors in both
familial cases and sporadic cases. Familial CRC has been associated with genetic changes …

(1) Background: MLH1 hypermethylation is an epigenetic alteration in the tumorigenesis of
colorectal cancer (CRC) and endometrial cancer (EC), causing gene silencing, and, as a …

Constitutional epimutation, which is an aberration in gene expression due to an altered
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …

Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has
been previously reported. We aimed to scan the genome for heritable methylation marks …

Background: Most mismatch repair–deficient (MMRd) colorectal cancer (CRC) cases arise
sporadically, associated with somatic MLH1 methylation, whereas approximately 20% have …