The recovery of stalled replication forks depends on the controlled resection of nascent DNA
and on the loading of cohesin. These processes operate in the context of nascent chromatin …

In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the
latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis …

Determining the balance between DNA double strand break repair (DSBR) pathways is
essential for understanding treatment response in cancer. We report a method for …

For inhibitor design, as in most research, the best system is question dependent. We
suggest structurally defined allostery to design specific inhibitors that target regions beyond …

The duplication of DNA is a fundamental process that is required for the transfer of the
genetic information from parent to daughter cells. Aberrant DNA replication processes are …

Most tumors lack the G1/S phase checkpoint and are insensitive to antigrowth signals. Loss
of G1/S control can severely perturb DNA replication as revealed by slow replication fork …

During the last decades, intensive efforts have been applied to tackle the enormous
emissions of CO2 into atmosphere. These efforts include not only developing efficient …

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