Compared with other mammals, the genomes of humans and other primates show an
enrichment of large, interspersed segmental duplications (SDs) with high levels of sequence …

Background We present the results of EGASP, a community experiment to assess the state-
of-the-art in genome annotation within the ENCODE regions, which span 1% of the human …

The sequence of the human genome encodes the genetic instructions for human
physiology, as well as rich information about human evolution. In 2001, the International …

The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …

The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential
component of the centrosome, underlying eukaryotic microtubule-based motility, cell division …

The recent advances in DNA sequencing technology are enabling a rapid increase in the
number of genomes being sequenced. However, many fundamental questions in genome …

The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …

Polymorphic variants on chromosomes are considered 'normal', as heterochromatin has no
coding potential and nucleolar organizing regions (NOR) contain genes coding for rRNA …

We used long-read DNA sequencing to assemble the genome of a Southern Han Chinese
male. We organized the sequence into chromosomes and filled in gaps using the recently …